KMID : 0367320120230030103
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Journal of the Korean Academy of Child and Adolescent Psychiatry 2012 Volume.23 No. 3 p.103 ~ p.108
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Change of Quality of Life in Children with ADHD after 12 Weeks OROS-Methylphenidate Treatment
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Kim Hyung-In
Kim Bung-Nyun Cho Soo-Churl Shin Min-Sup Yoo Hee-Jeong Kim Jae-Won Kim Ji-Hoon Son Jung-Woo Shin Yun-Mi Chung Un-Sun Han Doug-Hyun
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Abstract
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Objectives : The aim of this study is to investigate the effectiveness of treatment with osmotic-release oral system methylphenidate (OROS-MPH) on quality of life (QOL) in children with attention-deficit hyperactivity disorder (ADHD). Another aim is to assess the relationship between change in QOL and other factors including children¡¯s symptoms and academic performance or parents¡¯ depression and parenting stress.
Methods : A total of 111 medication-naive children with ADHD in a multicenter, open-label, 12-week trial of OROS-MPH completed an evaluation using diverse rating scales at two time points; at baseline and after 12 weeks of treatment. Scales for investigation of children included the Parent Report Form-Children¡¯s Health and Illness Profile-Children¡¯s Edition (PRF-CHIP-CE) on QOL, the ADHD Rating Scale-IV on symptoms, and the Academic Performance Rating Scale (APRS). The Beck Depression Inventory and Parenting Stress Index were used for assessment of their parents.
Results : Total scores for mean PRF-CHIP-CE increased from at baseline to after 12 weeks of treatment (p<.001). The change of APRS showed the strongest correlation with the increment of PRF-CHIP-CE scores (Pearson coefficient=0.561, p<.001), even after controlling for other factors (partial correlation coefficient=0.420, p<.001).
Conclusion : Treatment with MPH-OROS results in improvement of QOL in children with ADHD in Korea. The advance in academic performance plays a key role in this change of QOL.
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KEYWORD
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Quality of Life, Methylphenidate, Attention-Deficit Hyperactivity Disorder
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